Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Two microsatellite markers, tightly linked to CACNA1A, were genotyped in migraine with aura (MA) families to determine if this gene, which underlies the 19p13 linked forms of familial hemiplegic migraine, is also linked to MA. Two-point parametric lod and nonparametric linkage scores did not support linkage. Transmission disequilibrium testing provided no evidence for linkage of MA to CACNA1A. In a large dataset of 64 Canadian MA families, the authors did not find evidence to support an MA susceptibility gene in the region of 19p13.

Original publication

DOI

10.1212/wnl.59.7.1099

Type

Journal article

Journal

Neurology

Publication Date

08/10/2002

Volume

59

Pages

1099 - 1101

Keywords

Calcium Channels, Chromosomes, Human, Pair 19, Female, Genetic Linkage, Humans, Lod Score, Male, Microsatellite Repeats, Migraine with Aura, Pedigree, Prevalence