Synthesis and Crystal Structures of (RS, RS, RS)- and (1 RS,2 RS,3 SR)-3-(N-Methylamino)cyclohexane-1,2-diol
Davies SG., Hewings DS., Kurosawa W., Lee JA., Roberts PM., Thompson AL., Thomson JE.
Abstract: 3-(N-Methylamino)cyclohexane-1,2-diols (RS, RS, RS)-25 and (1 RS,2 RS,3 SR)-26 were synthesised and their crystal structures were studied by X-ray diffraction. Compound 25 co-crystallizes with chloroform in the orthorhombic space group P na2 with cell parameters of a = 11.8550(2) Å, b = 19.8293(4) Å, c = 10.6163(2) Å, V = 2495.64(8) Å and Z = 8. Compound 26 crystallizes in the triclinic space group P-1 with cell parameters of a = 13.1019(3) Å, b = 15.0122(3) Å, c = 18.5562(5) Å, α = 95.3082(8)°, β = 90.3738(10)°, γ = 115.2775(9)°, V = 3281.87(14) Å and Z = 16. Both structures were characterised by arrays of hydrogen bonding interactions. Graphical Abstract: (RS, RS, RS)-3-(N-Methylamino)cyclohexane-1,2-diol and (1 RS,2 RS,3 SR)-3-(N-Methylamino)cyclohexane-1,2-diol were synthesised and their structures were studied by X-ray diffraction.[Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York.