A succinct asymmetric synthesis of (2 S,3 R)-2-methyl-3-aminopentanoic acid hydrochloride
Davies SG., Ichihara O., Walters IAS.
© 1993 Georg Thieme Verlag, Rudigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. The highly stereoselective conjugate addition of lithium (R)-(α-methylbenzyl)benzylamide (R)-2 to tert-butyl (E)-2-methyl-2-pentenoate 3 affords a straightforward synthesis of (2S,3R)-2-methyl-3-aminopentanoic acid 1 as its hydrochloride salt 5.